QSAR Model for Drug Human Oral Bioavailability.
نویسندگان
چکیده
منابع مشابه
Oral Transmucosal Delivery for Improved Drug Bioavailability and Patient Compliance
Since last 15 years the number of 505(b)(2) filings with new dosage forms for existing drug molecules at United states Food and Drug Administration (USFDA) has been increased tremendously. This is because of the tremendous increase in the developmental cost of new chemical entities (NCE) and increased concerns about patient preferences and market demands for the novel unconventional dosage form...
متن کاملEvaluation of Lipid-based Drug Delivery System (Phytosolve) on Oral Bioavailability of Dibudipine
Abstract The objective of present study was to evaluate pharmacokinetic parameters of dibudipine Phytosolve after oral administration in rats. The solubility test was carried out to select suitable oily solvent for dibudipine. Phytosolve formulation was prepared with a medium chain triglyceride (MCT) oil (20%), soybean phospholipids (5%) and a 70% fructose solution (75%). The effect of polyol c...
متن کاملPrediction and mechanistic interpretation of human oral drug absorption using MI-QSAR analysis.
Membrane-interaction [MI]-QSAR analysis, which includes descriptors explicitly derived from simulations of solutes [drugs] interacting with phospholipid membrane models, was used to construct QSAR models for human oral intestinal drug absorption. A data set of 188 compounds, which are mainly drugs, was divided into a parent training set of 164 compounds and a test set of 24 compounds. Stable, b...
متن کاملOral Absorption, Intestinal Metabolism and Human Oral Bioavailability
Most of the drugs that are available in the marketplace are administered via the oral route, which is a convenient and cost effective route of administration (Lipinski 1995; Lipinski 2000; Lipinski et al. 2001; Lipinski 2004; Abrahamsson and Lennernas 2005). Thus, oral bioavailability is one of the key considerations for discovery and development of a new chemical entity (NCE). It is well recog...
متن کاملEvaluation of Lipid-based Drug Delivery System (Phytosolve) on Oral Bioavailability of Dibudipine
Abstract The objective of present study was to evaluate pharmacokinetic parameters of dibudipine Phytosolve after oral administration in rats. The solubility test was carried out to select suitable oily solvent for dibudipine. Phytosolve formulation was prepared with a medium chain triglyceride (MCT) oil (20%), soybean phospholipids (5%) and a 70% fructose solution (75%). The effect of polyol c...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2000
ISSN: 0022-2623,1520-4804
DOI: 10.1021/jm000397h